524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

524400
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₃₆H₅₆O₈ 16561-29-8

      Precios y disponibilidad

      Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
      US1524400-1MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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      Debe confirmarse disponibilidad
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          El resto: se avisará
          Se avisará
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          Contact Customer Service

          Frasco de vidrio 1 mg
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          Description
          OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
          Catalogue Number524400
          Brand Family Calbiochem®
          SynonymsTPA, PMA, PKC Activator I
          References
          ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.
          Product Information
          CAS number16561-29-8
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₆H₅₆O₈
          Chemical formulaC₃₆H₅₆O₈
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
          Biological Information
          Primary TargetProtein Kinase C
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQH4377000
          Safety Information
          R PhraseR: 21-38

          Harmful in contact with skin.
          Irritating to skin.
          S PhraseS: 26-27-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Take off immediately all contaminated clothing.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          524400

          Referencias bibliográficas

          Visión general referencias
          Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.

          Folleto

          Cargo
          Caspases and other Apoptosis Related Tools Brochure

          Citas

          Título
        • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
        • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
        • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
        • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-October-2010 JSW
          SynonymsTPA, PMA, PKC Activator I
          DescriptionExtremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number16561-29-8
          RTECSQH4377000
          Chemical formulaC₃₆H₅₆O₈
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
          Toxicity Harmful
          ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
          Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
          Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
          Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
          Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
          Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
          Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
          Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
          Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
          Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
          Perchellet, J. 1985. Carcinogenesis 6, 567.
          Nishizuka, Y. 1984. Science 255, 1365.
          Mastro, A. 1982. Lymphokines 6, 263.
          Citation
        • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
        • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
        • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
        • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.