100066 NF-κB Activation Inhibitor V, 5HPP-33

100066
  
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      Áttekintés

      Replacement Information

      Kulcsspecifikációk táblázata

      Empirical FormulaCAS #
      C₂₀H₂₁NO₃ 105624-86-0
      Description
      Overview

      This product has been discontinued.





      A cell-permeable N-phenylpthalimide compound that exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. Shown to exhibit potent inhibitory activity against IL-1-induced NF-κB translocation in HeLa cells (IC50 = 530 nM) and paclitaxel-like antimicrotubule activity. Effectively suppresses the proliferation of various cancer cells, including several Paclitaxel-resistant lines.
      Catalogue Number100066
      Brand Family Calbiochem®
      Synonyms5HPP-33, 5-Hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
      References
      Referencesde-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
      Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
      Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.
      Product Information
      CAS number105624-86-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₂₁NO₃
      Chemical formulaC₂₀H₂₁NO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetIL-1-induced NF-κB translocation
      Primary Target IC<sub>50</sub>530 nM inhibiting IL-1-induced NF-κB translocation in HeLa cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      100066

      References

      Hivatkozások áttekintése
      de-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
      Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
      Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms5HPP-33, 5-Hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
      DescriptionA cell-permeable N-phenylpthalimide compound that exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. Shown to exhibit potent inhibitory activity against IL-1-induced NF-κB translocation in HeLa cells (IC50 = 530 nM) and paclitaxel-like antimicrotubule activity. Effectively suppresses the proliferation of various cancer cells, including several Paclitaxel-resistant lines.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number105624-86-0
      Chemical formulaC₂₀H₂₁NO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      Referencesde-Blanco, E. J., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6031.
      Li, P. K., et al. 2006. Mol. Cancer Ther. 5, 450.
      Inatsuki, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 321.