05-23-0150 | [Arg⁸]-Vasopressin

05-23-0150
  
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      Overview

      Replacement Information
      Description
      OverviewSynthetic [Arg8]-Vasopressin. An antidiuretic peptide hormone. Released from the hypothalamus during stress. Although noted primarily for its hemodynamic and hemostatic properties, it appears to affect the immune system. Acts via the activation of the adenylate cyclase system resulting in increased cAMP levels (EC50 = 34 nM). Reported to induce an increase in [Ca2+]i in hippocampal neurons via action of VI vasopressin receptors coupled with N-type Ca2+ channels.
      Catalogue Number05-23-0150
      Brand Family Calbiochem®
      SynonymsAVP
      References
      ReferencesMihara, T., et al. 1999. Brain Res. Bull. 49, 343.
      Kobayashi, H., et al. 1994. Brain Res. 647, 145.
      Monaghan, M.L., et al. 1993. Gen. Pharmacol. 24, 1013.
      Product Information
      CAS number113-79-1
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₆H₆₅N₁₅O₁₂S₂
      Chemical formulaC₄₆H₆₅N₁₅O₁₂S₂
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Cys¹-Tyr-Phe-Gln-Asn-Cys⁶-Pro-Arg-Gly-NH₂ (disulfide bond: 1 → 6)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20

      Harmful by inhalation.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      05-23-0150

      References

      Reference overview
      Mihara, T., et al. 1999. Brain Res. Bull. 49, 343.
      Kobayashi, H., et al. 1994. Brain Res. 647, 145.
      Monaghan, M.L., et al. 1993. Gen. Pharmacol. 24, 1013.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-August-2008 JSW
      SynonymsAVP
      DescriptionSynthetic [Arg8]-Vasopressin. An anti-diuretic peptide hormone. Released from the hypothalamus during stress. Although noted primarily for its hemodynamic and hemostatic properties, it appears to affect the immune system. Acts via the activation of the adenylate cyclase system resulting in increased cAMP levels (EC50 = 34 nM).
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      CAS number113-79-1
      Chemical formulaC₄₆H₆₅N₁₅O₁₂S₂
      Peptide SequenceH-Cys¹-Tyr-Phe-Gln-Asn-Cys⁶-Pro-Arg-Gly-NH₂ (disulfide bond: 1 → 6)
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      Merck USA index14 9938
      ReferencesMihara, T., et al. 1999. Brain Res. Bull. 49, 343.
      Kobayashi, H., et al. 1994. Brain Res. 647, 145.
      Monaghan, M.L., et al. 1993. Gen. Pharmacol. 24, 1013.