171596 β-Amyloid Peptide (1-42), Rat

171596
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      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1171596-250UG
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      In Stock 
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          Plastic ampoule 250 μg
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          Description
          OverviewPredominant peptide found in the brain of patients with Alzheimer’s Disease and Down’s Syndrome. Promotes down-regulation of Bcl-2 and upregulation of Bax expression in neurons.
          Catalogue Number171596
          Brand Family Calbiochem®
          SynonymsDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
          References
          ReferencesParadis, E., et al. 1996. J. Neurosci. 16, 7533.
          Roher, A.E., et al. 1996. J. Biol. Chem. 271, 20631.
          Soto, C., and Castano, E.M. 1996. Biochem. J. 314, 701.
          Murrell, J., et al. 1991. Science 254, 97.
          Goldgaber, D., et al. 1987. Science 235, 877.
          Kang, J., et al. 1987. Nature 325, 733.
          Product Information
          CAS number107761-42-2
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₉₉H₃₀₇N₅₃O₅₉S
          Chemical formulaC₁₉₉H₃₀₇N₅₃O₅₉S
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥80% by HPLC
          Physicochemical Information
          Peptide SequenceH-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          171596

          References

          Reference overview
          Paradis, E., et al. 1996. J. Neurosci. 16, 7533.
          Roher, A.E., et al. 1996. J. Biol. Chem. 271, 20631.
          Soto, C., and Castano, E.M. 1996. Biochem. J. 314, 701.
          Murrell, J., et al. 1991. Science 254, 97.
          Goldgaber, D., et al. 1987. Science 235, 877.
          Kang, J., et al. 1987. Nature 325, 733.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-April-2008 RFH
          SynonymsDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
          Descriptionβ-Amyloid Peptide (Aβ) is the main constituent in both senile plaques and diffuse deposits in Alzheimer's diseased brains. Under appropriate conditions, the soluble amyloid peptides aggregate into the fibrils associated with the disease state. It has proposed that Aβ peptide may increase the sensitivity of neurons to oxidative damage by downregulating expression of bcl-2, a key anti-apoptotic protein and upregulating of bax expression, a protein known to induce cell death.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          CAS number107761-42-2
          Chemical formulaC₁₉₉H₃₀₇N₅₃O₅₉S
          Peptide SequenceH-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
          Purity≥80% by HPLC
          Solubility5% Acetic Acid (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesParadis, E., et al. 1996. J. Neurosci. 16, 7533.
          Roher, A.E., et al. 1996. J. Biol. Chem. 271, 20631.
          Soto, C., and Castano, E.M. 1996. Biochem. J. 314, 701.
          Murrell, J., et al. 1991. Science 254, 97.
          Goldgaber, D., et al. 1987. Science 235, 877.
          Kang, J., et al. 1987. Nature 325, 733.