100065 | 2-APB - CAS 524-95-8 - Calbiochem

100065
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₄H₁₆BNO524-95-8

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1100065-100MG
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          Glass bottle 100 mg
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          Description
          OverviewA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.
          Catalogue Number100065
          Brand Family Calbiochem®
          Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
          References
          ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
          Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
          Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
          Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
          Maruyama, T., et al. 1997. J. Biochem. 122, 498.
          Product Information
          CAS number524-95-8
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₁₄H₁₆BNO
          Chemical formulaC₁₄H₁₆BNO
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIns(1,4,5)P3-induced Ca2+ release
          Primary Target IC<sub>50</sub>42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
          Purity≥97% by titration
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSED6150000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          100065

          References

          Reference overview
          Brooke, R. T., et al. 2004. Lab. Invest. 84, 29.
          Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
          Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
          Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
          Maruyama, T., et al. 1997. J. Biochem. 122, 498.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure

          Citations

          Title
        • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-July-2009 RFH
          Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
          DescriptionA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number524-95-8
          RTECSED6150000
          Chemical formulaC₁₄H₁₆BNO
          Structure formulaStructure formula
          Purity≥97% by titration
          SolubilityDMSO (20 mg/ml) and 95% Ethanol (25 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
          Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
          Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
          Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
          Maruyama, T., et al. 1997. J. Biochem. 122, 498.
          Citation
        • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.