164603 | 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

164603
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₃H₅NO₄504-88-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1164603-50MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 50 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
          Catalogue Number164603
          Brand Family Calbiochem®
          Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
          References
          ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
          Product Information
          CAS number504-88-1
          FormLight yellow powder
          Hill FormulaC₃H₅NO₄
          Chemical formulaC₃H₅NO₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25-36/37/38

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          164603

          References

          Reference overview
          Beal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2012 JSW
          Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
          DescriptionA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
          FormLight yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number504-88-1
          Chemical formulaC₃H₅NO₄
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO or Ethanol (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.