171588 | Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem

171588
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₅H₄₆N₆O₈

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1171588-5MG
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      Limited AvailabilityLimited Availability
      In Stock 
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          Plastic ampoule 5 mg
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          Description
          OverviewA modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 > 24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).
          Catalogue Number171588
          Brand Family Calbiochem®
          SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
          References
          ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₅H₄₆N₆O₈
          Chemical formulaC₃₅H₄₆N₆O₈
          ReversibleN
          Applications
          Biological Information
          Primary TargetReduction in Aβ deposits
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          171588

          References

          Reference overview
          Permanne, B., et al. 2002. FASEB J. 16, 860.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-April-2008 RFH
          SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
          DescriptionA modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood/brain barrier and acts as a β-sheet breaker. Increases neuronal survival with a concomitant reduction in brain inflammation by inducing a dramatic reduction in Aβ deposition in a transgenic mouse model of Alzheimer's disease. Displays greater stability against proteolytic degradation (t½ > 24 h in human plasma and cerebrospinal fluid; ~37 min in blood).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₅H₄₆N₆O₈
          Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.