100128 A77 1726 - CAS 108605-62-5 - Calbiochem

100128
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₂H₉F₃N₂O₂108605-62-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1100128-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewLeflunomide metabolite that blocks TNF-dependent NF-κB activation and gene expression. Inhibits the activity of dihydroorotate dehydrogenase (DHO-DH; IC50 = 220 nM). Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts. Inhibits IL-1β-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells. A cell-permeable, reversible, and substrate competitive inhibitor that inhibits the IL-2-induced tyrosine phosphorylation of JAK1 and JAK3.
          Catalogue Number100128
          Brand Family Calbiochem®
          SynonymsN-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide
          References
          ReferencesJankovic, V., et al. 2000. Cell Immunol. 199, 73.
          Hamilton, L.C., et al. 1999. Br. J. Pharmacol. 127, 1589.
          Manna, S.K., and Aggarwal, B.B. 1999. J. Immunol. 162, 2095.
          Elder, R.T., et al. 1997. J. Immunol. 159, 22.
          Xu, X., et al. 1996. Biochem. Pharmacol. 52, 527.
          Xu, X., et al. 1995. J. Biol. Chem. 270, 12398.
          Mattar, T., et al. 1993. FEBS Lett. 334, 161.
          Product Information
          CAS number108605-62-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₂H₉F₃N₂O₂
          Chemical formulaC₁₂H₉F₃N₂O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetDihydroorotate dehydrogenase (DHO-DH)
          Primary Target IC<sub>50</sub>220 nM against DHO-DH
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          100128

          References

          Reference overview
          Jankovic, V., et al. 2000. Cell Immunol. 199, 73.
          Hamilton, L.C., et al. 1999. Br. J. Pharmacol. 127, 1589.
          Manna, S.K., and Aggarwal, B.B. 1999. J. Immunol. 162, 2095.
          Elder, R.T., et al. 1997. J. Immunol. 159, 22.
          Xu, X., et al. 1996. Biochem. Pharmacol. 52, 527.
          Xu, X., et al. 1995. J. Biol. Chem. 270, 12398.
          Mattar, T., et al. 1993. FEBS Lett. 334, 161.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          SynonymsN-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide
          DescriptionLeflunomide metabolite that blocks TNF-dependent NF-κB activation and gene expression. Inhibits the activity of dihydroorotate dehydrogenase (DHO-DH; IC50 = 220 nM). Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts. Inhibits IL-1β-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells.A cell-permeable, reversible and substrate competitive inhibitor that inhibits the IL-2-induced tyrosine phosphorylation of JAK1 and JAK3.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number108605-62-5
          Chemical formulaC₁₂H₉F₃N₂O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (35 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
          Toxicity Carcinogenic / Teratogenic
          ReferencesJankovic, V., et al. 2000. Cell Immunol. 199, 73.
          Hamilton, L.C., et al. 1999. Br. J. Pharmacol. 127, 1589.
          Manna, S.K., and Aggarwal, B.B. 1999. J. Immunol. 162, 2095.
          Elder, R.T., et al. 1997. J. Immunol. 159, 22.
          Xu, X., et al. 1996. Biochem. Pharmacol. 52, 527.
          Xu, X., et al. 1995. J. Biol. Chem. 270, 12398.
          Mattar, T., et al. 1993. FEBS Lett. 334, 161.