123850 AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

123850
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₃H₉BrO₃4906-68-7

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1123850-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
          Catalogue Number123850
          Brand Family Calbiochem®
          SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
          References
          ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
          El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
          Product Information
          CAS number4906-68-7
          FormWhite solid
          Hill FormulaC₁₃H₉BrO₃
          Chemical formulaC₁₃H₉BrO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥94% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
          El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-July2-2012 JSW
          SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
          DescriptionA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number4906-68-7
          Chemical formulaC₁₃H₉BrO₃
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
          El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.