171263 | AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem

171263
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₈H₁₉N₃O₃S280112-24-5

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      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1171263-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
          Catalogue Number171263
          Brand Family Calbiochem®
          Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
          Application Data
          References
          ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
          Product Information
          CAS number280112-24-5
          FormOff-white solid
          Hill FormulaC₁₈H₁₉N₃O₃S
          Chemical formulaC₁₈H₁₉N₃O₃S
          Applications
          ApplicationThe AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This AMPK activator and small molecule/inhibitor is primarily used for Biochemicals applications.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          171263

          References

          Reference overview
          Lemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2012 JSW
          Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
          Application Data
          DescriptionA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number280112-24-5
          Chemical formulaC₁₈H₁₉N₃O₃S
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml; clear, colorless solution). Warming to 55-60°C is required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.