171258 | AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem

171258
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₁₂N₂O₃S844499-71-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1171258-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable thienopyridone compound that acts as a direct, potent, selective, reversible, and allosteric activator of AMPK (EC50 = 0.8 µM, 1.9 µM and 2.2 µM in partially purified AMPK from rat liver, muscle and heart, respectively; 0.7 µM for AMPKα1,β1,γ1 isoform and 1.1 µM in HEK cells). Acts by inhibiting the dephosphorylation of AMPKT172. Does neither affect GPPase and FBPase activities at 100 µM, and a panel of 67-receptors and ion-channels at 10 µM nor alter the intracellular levels of ATP and AMP. Specifically stimulates hepatic AMPK in ob/ob mouse model (30 mg/kg, i.p.), improves insulin-sensitivity and regulates glucose and lipid metabolism. Shown to reduce mRNA expression levels of several gluconeogenic enzymes.
          Catalogue Number171258
          Brand Family Calbiochem®
          Synonyms6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
          References
          ReferencesSanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
          Cool, B., et al. 2006. Cell Metab. 3, 403.
          Product Information
          CAS number844499-71-4
          FormOff-white solid
          Hill FormulaC₂₀H₁₂N₂O₃S
          Chemical formulaC₂₀H₁₂N₂O₃S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsSoluble in DMSO (mg/ml), EtOH (mg/ml); aliquot and store at -20*C; stable for 6 months.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          171258

          References

          Reference overview
          Sanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
          Cool, B., et al. 2006. Cell Metab. 3, 403.