110123 Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

110123
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₃₂H₄₈O₅67416-61-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1110123-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
          Catalogue Number110123
          Brand Family Calbiochem®
          SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
          References
          ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
          Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
          Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
          Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
          Product Information
          CAS number67416-61-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₂H₄₈O₅
          Chemical formulaC₃₂H₄₈O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-lipoxygenase
          Primary Target IC<sub>50</sub>1.5 µM against 5-lipoxygenase in rat PMNLs
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          110123

          References

          Reference overview
          Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
          Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
          Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
          Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2010 JSW
          SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
          DescriptionA cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number67416-61-9
          Chemical formulaC₃₂H₄₈O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
          Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
          Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
          Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.