129935 | Actinomycin D, 7-Amino- - CAS 7240-37-1 - Calbiochem

129935
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₆₂H₈₇N₁₃O₁₆7240-37-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1129935-1MG
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          Glass bottle 1 mg
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          Description
          Overview7-Aminoactinomycin D, like its parent molecule, actinomycin D, is a DNA intercalator and has antibacterial properties. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. Fluorescent excitation and emission maxima are 500 and 672 nm, respectively. Complexes with DNA and absorbs at 555 nm and emits at 655 nm. Useful in distinguishing early apoptotic cells, which have lost membrane integrity, from apoptotic and live cells. Has been used in DNA analysis and as a probe for chromosome structure and function.
          Catalogue Number129935
          Brand Family Calbiochem®
          Synonyms7-AAD, 7-Amino-AMD, 7-Aminoactinomycin C₁, 7-Aminodactinomycin
          References
          ReferencesSchmid, I., et al. 1994. J. Immunol. Methods 170, 145.
          Berg, R.J., et al. 1993. Carcinogenesis 14, 103.
          Chen, F.M. 1992. Biochemistry 31, 6223.
          Schmid, I., et al. 1992. Cytometry 13, 204.
          Toba, K., et al. 1992. Cytometry 13, 60.
          Sengupta, S.K., et al. 1975. J. Med. Chem. 18, 1175.
          Product Information
          CAS number7240-37-1
          FormReddish-purple solid
          Hill FormulaC₆₂H₈₇N₁₃O₁₆
          Chemical formulaC₆₂H₈₇N₁₃O₁₆
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          ApplicationActinomycin D, 7-Amino, CAS 7240-37-1, is a DNA intercalator that complexes with DNA. Absorbs at 555 nm & emits at 655 nm. Exhibits growth-inhibitory activity against certain leukemias and sarcomas.
          Biological Information
          Primary Targetleukemias and sarcomas
          Purity≥85% by HPLC
          Sample TypeIntact Cells
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSAU1579000
          Safety Information
          R PhraseR: 28

          Very toxic if swallowed.
          S PhraseS: 36/37-45-28

          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          129935

          References

          Reference overview
          Schmid, I., et al. 1994. J. Immunol. Methods 170, 145.
          Berg, R.J., et al. 1993. Carcinogenesis 14, 103.
          Chen, F.M. 1992. Biochemistry 31, 6223.
          Schmid, I., et al. 1992. Cytometry 13, 204.
          Toba, K., et al. 1992. Cytometry 13, 60.
          Sengupta, S.K., et al. 1975. J. Med. Chem. 18, 1175.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Dyes and Stains Technical Bulletin

          Citations

          Title
        • Jeffrey D. Price, et al. (2005) Induction of a regulatory phenotype in human CD4+ T cells by Streptococcal M protein. Journal of immunology 175, 677-684.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-August-2010 JSW
          Synonyms7-AAD, 7-Amino-AMD, 7-Aminoactinomycin C₁, 7-Aminodactinomycin
          Description7-Aminoactinomycin D is a membrane impermeable fluorescent DNA intercalator. Like its parent compound, Actinomycin D (Cat. No. 114666), 7-AAD has antibacterial properties and growth inhibitory activity against certain leukemias and sarcomas. Useful for flow cytometry and fluorescence microscopy. Used for staining nonviable cells and for identifying apoptotic cells. Compatible with FITC and PE cell surface staining. The absorption/emission maxima are as follows: unbound (ex. 500 nm, em. 672 nm) and DNA bound (ex. 555 nm, em. 655 nm). λmax 528 nm ± 2; εmax = 22,700 ± 5,000 M-1 cm-1
          FormReddish-purple solid
          CAS number7240-37-1
          RTECSAU1579000
          Chemical formulaC₆₂H₈₇N₁₃O₁₆
          Structure formulaStructure formula
          Purity≥85% by HPLC
          SolubilityDMSO (20 mg/ml) or Ethanol (5 mg/ml). Further dilute in aqueous buffers just prior to use.
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Highly Toxic
          Merck USA index14, 2800
          ReferencesSchmid, I., et al. 1994. J. Immunol. Methods 170, 145.
          Berg, R.J., et al. 1993. Carcinogenesis 14, 103.
          Chen, F.M. 1992. Biochemistry 31, 6223.
          Schmid, I., et al. 1992. Cytometry 13, 204.
          Toba, K., et al. 1992. Cytometry 13, 60.
          Sengupta, S.K., et al. 1975. J. Med. Chem. 18, 1175.
          Citation
        • Jeffrey D. Price, et al. (2005) Induction of a regulatory phenotype in human CD4+ T cells by Streptococcal M protein. Journal of immunology 175, 677-684.