119135 Adenosine A1 Receptor Agonist I, CPA - CAS 41552-82-3 - Calbiochem

119135
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      Overview

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      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1119135-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA potent and selective agonist of adenosine A1 receptor (A1R) (Ki = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).
          Catalogue Number119135
          Brand Family Calbiochem®
          Synonyms(2R,3R,4S,5R)-2-(6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, N6-Cyclopentyl-adenosine
          References
          ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
          Monopoli, A., et al. 1994. Arzneimittelforschung. 44, 1305.
          Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
          Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
          Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.
          Product Information
          CAS number41552-82-3
          FormWhite solid
          Hill FormulaC₁₅H₂₁N₅O₄
          Chemical formulaC₁₅H₂₁N₅O₄
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA1
          Primary Target K<sub>i</sub>0.8 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Migita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
          Monopoli, A., et al. 1994. Arzneimittelforschung. 44, 1305.
          Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
          Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
          Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          Synonyms(2R,3R,4S,5R)-2-(6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, N6-Cyclopentyl-adenosine
          DescriptionA potent and selective agonist of adenosine A1 receptor (A1R) (Ki = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number41552-82-3
          Chemical formulaC₁₅H₂₁N₅O₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mM), 1N HCl (100 mM), or Ethanol (25 mM; slight warming is required for complete solubilization in ethanol)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
          Monopoli, A., et al. 1994. Arzneimittelforschung. 44, 1305.
          Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
          Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
          Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.