119147 Adenosine A1 Receptor Antagonist I, DPCPX - CAS 102146-07-6 - Calbiochem

119147
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      Overview

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      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1119147-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
          Catalogue Number119147
          Brand Family Calbiochem®
          Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
          References
          ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Blood, A. B., et al. 2003. J Physiol. 553, , 935.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
          Product Information
          CAS number102146-07-6
          FormWhite solid
          Hill FormulaC₁₆H₂₄N₄O₂
          Chemical formulaC₁₆H₂₄N₄O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA1
          Primary Target K<sub>i</sub>3.9 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          119147

          References

          Reference overview
          Migita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Blood, A. B., et al. 2003. J Physiol. 553, , 935.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
          DescriptionA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number102146-07-6
          Chemical formulaC₁₆H₂₄N₄O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (5 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
          Blood, A. B., et al. 2003. J Physiol. 553, , 935.
          Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
          Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.