123871 | Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem

123871
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      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1123871-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo.
          Catalogue Number123871
          Brand Family Calbiochem®
          SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
          References
          ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
          Product Information
          CAS number305834-79-1
          FormOff-white solid
          Hill FormulaC₁₇H₁₇ClN₂O₅
          Chemical formulaC₁₇H₁₇ClN₂O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPleckstrin homology (PH) domain of Akt
          Purity≥98% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          123871

          References

          Reference overview
          Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-November-2013 JSW
          SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
          DescriptionA cell-permeable and blood-brain barrier permeant bromo-to-chloro substituted HA14-1 (Cat. No. 371971) analog that renders Akt in a conformation susceptible to phosphorylation by upstream kinases via specific interaction with Akt pleckstrin homology (PH) domain PtdIns(3,4,5)P3- (PIP3) binding pocket. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473) in a time- and dose-dependent manner (2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO (middle cerebral artery occlusion) model (40 mg/kg, i.p.) in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number305834-79-1
          Chemical formulaC₁₇H₁₇ClN₂O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC (sum of two isomers)
          SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.