124037 | Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

124037
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₈ClNO28755-03-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1124037-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50 = 30 mg/kg; 5 times/wk for 3 wks via p.o.) in vivo.
          Catalogue Number124037
          Brand Family Calbiochem®
          Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
          References
          ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
          Product Information
          CAS number28755-03-5
          FormPink solid
          Hill FormulaC₁₀H₈ClNO
          Chemical formulaC₁₀H₈ClNO
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          124037

          References

          Reference overview
          Kim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-July-2012 JSW
          Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
          DescriptionA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.
          FormPink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number28755-03-5
          Chemical formulaC₁₀H₈ClNO
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.