129876 | Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

129876
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₆H₈ClN₇O • HCl2016-88-8

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1129876-100MG
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          Alu drum 100 mg
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          Description
          OverviewAn inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
          Catalogue Number129876
          Brand Family Calbiochem®
          SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
          References
          ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
          Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
          Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
          Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
          Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
          Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
          Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
          Product Information
          CAS number2016-88-8
          ATP CompetitiveN
          FormOff-white to yellow solid
          Hill FormulaC₆H₈ClN₇O • HCl
          Chemical formulaC₆H₈ClN₇O • HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcapillary morphogenesis
          Primary Target IC<sub>50</sub>130 µM inhibiting capillary morphogenesis completely and reversibly
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUQ2275500
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 45-36

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          129876

          References

          Reference overview
          Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
          Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
          Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
          Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
          Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
          Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
          Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.

          Brochure

          Title
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-April-2009 JSW
          SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
          DescriptionAn inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
          FormOff-white to yellow solid
          CAS number2016-88-8
          RTECSUQ2275500
          Chemical formulaC₆H₈ClN₇O • HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (2.5 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          Merck USA index14, 406
          ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
          Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
          Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
          Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
          Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
          Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
          Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.