176880 Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem

176880
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₄H₁₉NO₄22862-76-6

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1176880-10MG
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          Alu drum 10 mg
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          Description
          OverviewStrongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
          Catalogue Number176880
          Brand Family Calbiochem®
          Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
          References
          ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
          Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
          Kyriakis, J.M., et al. 1994. Nature 369, 156.
          Sanchez, I., et al. 1994. Nature 372, 794.
          Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
          Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.
          Product Information
          CAS number22862-76-6
          FormWhite solid
          Hill FormulaC₁₄H₁₉NO₄
          Chemical formulaC₁₄H₁₉NO₄
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAnisomycin, Streptomyces griseolus, CAS 22862-76-6, acts as an inhibitor of protein synthesis at the translation step. Strongly activates JNK/SAPK and p38 MAP kinase in mammalian cells.
          Biological Information
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSBZ9800000
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          176880

          References

          Reference overview
          Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
          Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
          Kyriakis, J.M., et al. 1994. Nature 369, 156.
          Sanchez, I., et al. 1994. Nature 372, 794.
          Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
          Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.

          Brochure

          Title
          Antibiotics Profiler
          Caspases and other Apoptosis Related Tools Brochure
          MAP Kinases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-June-2009 RFH
          Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
          DescriptionActivates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
          FormWhite solid
          CAS number22862-76-6
          RTECSBZ9800000
          Chemical formulaC₁₄H₁₉NO₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (100 mg/ml) or Methanol (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
          Toxicity Toxic
          Merck USA index14, 670
          ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
          Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
          Kyriakis, J.M., et al. 1994. Nature 369, 156.
          Sanchez, I., et al. 1994. Nature 372, 794.
          Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
          Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.