182540 Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem

182540
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₁N₃O₄331684-05-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      US1182540-1MG
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      In Stock 
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
          Catalogue Number182540
          Brand Family Calbiochem®
          Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
          References
          ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.
          Product Information
          CAS number331684-05-0
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₇H₁₁N₃O₄
          Chemical formulaC₁₇H₁₁N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP450 arom.
          Primary Target IC<sub>50</sub>40 nM against P450arom
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          182540

          References

          Reference overview
          Recanatini, M., et al. 2001. J. Med. Chem. 44, 672.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
          DescriptionA potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331684-05-0
          Chemical formulaC₁₇H₁₁N₃O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.