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|US1203891-10MG||Glass bottle||10 mg||
|Overview||A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490 nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol (Cat. No. 212385) stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46 µM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr3 (Cat. No. 648490), and Pyr10 (Cat. No. 648494) in Ca2+ signaling studies.|
|References||Schleifer, H., et al. 2012. Br. J. Pharmacol. 167, 1712.|
|Form||Light beige solid|
|Structure formula Image|
|Primary Target IC<sub>50</sub>||490 nM|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Schleifer, H., et al. 2012. Br. J. Pharmacol. 167, 1712.|
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