03-34-0051 | Calpeptin - CAS 117591-20-5 - Calbiochem

03-34-0051
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₃₀N₂O₄117591-20-5

      Pricing & Availability

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      US103340051-100MG
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          Plastic ampoule 100 mg
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          US103340051-25MG
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              Plastic ampoule 25 mg
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              US103340051-5MG
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                  Plastic ampoule 5 mg
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                  Description
                  OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
                  Catalogue Number03-34-0051
                  Brand Family Calbiochem®
                  SynonymsBenzyloxycarbonylleucyl-norleucinal
                  References
                  ReferencesLee, M.S., et al. 2000. Nature 405, 360.
                  Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
                  Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
                  Shiba, E., et al. 1996. Anticancer Res. 16, 773.
                  Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
                  Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
                  Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
                  Product Information
                  CAS number117591-20-5
                  ATP CompetitiveN
                  FormWhite to off-white solid
                  Hill FormulaC₂₀H₃₀N₂O₄
                  Chemical formulaC₂₀H₃₀N₂O₄
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Applications
                  ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
                  Biological Information
                  Primary TargetCalpain-1
                  Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
                  Purity≥94% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Peptide SequenceZ-Leu-Nle-CHO
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  Certificates of Analysis

                  TitleLot Number
                  03-34-0051

                  References

                  Reference overview
                  Lee, M.S., et al. 2000. Nature 405, 360.
                  Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
                  Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
                  Shiba, E., et al. 1996. Anticancer Res. 16, 773.
                  Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
                  Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
                  Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

                  Brochure

                  Title
                  Calcium Metabolism and Related Products Brochure

                  Citations

                  Title
                • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
                • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision08-October-2007 JSW
                  SynonymsBenzyloxycarbonylleucyl-norleucinal
                  DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
                  FormWhite to off-white solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number117591-20-5
                  Chemical formulaC₂₀H₃₀N₂O₄
                  Peptide SequenceZ-Leu-Nle-CHO
                  Structure formulaStructure formula
                  Purity≥94% by HPLC
                  SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                  Toxicity Standard Handling
                  ReferencesLee, M.S., et al. 2000. Nature 405, 360.
                  Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
                  Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
                  Shiba, E., et al. 1996. Anticancer Res. 16, 773.
                  Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
                  Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
                  Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
                  Citation
                • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
                • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.