05-23-3800 | Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

05-23-3800
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀₉H₁₅₉N₂₅O₃₂S₅117399-94-7

      Pricing & Availability

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      US105233800-0.1MG
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          Plastic ampoule .1 mg
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          US105233800-0.5MG
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              Plastic ampoule .5 mg
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              US105233800-1MG
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                  Plastic ampoule 1 mg
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                  Description
                  OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
                  Catalogue Number05-23-3800
                  Brand Family Calbiochem®
                  SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
                  References
                  ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
                  Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
                  Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
                  Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
                  Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
                  Yanagisawa, M., et al. 1988. Nature 332, 411.
                  Product Information
                  CAS number117399-94-7
                  ATP CompetitiveN
                  FormWhite to off-white solid
                  FormulationSupplied as an acetate salt.
                  Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
                  Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
                  ReversibleN
                  Sold on the basis of peptide contentY
                  Applications
                  Biological Information
                  Primary TargetPotent vasoconstrictive action
                  Purity≥96% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Peptide ContentY
                  Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Protect from Moisture Protect from moisture
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  Certificates of Analysis

                  TitleLot Number
                  05-23-3800

                  References

                  Reference overview
                  Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
                  Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
                  Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
                  Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
                  Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
                  Yanagisawa, M., et al. 1988. Nature 332, 411.
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision12-May-2008 JSW
                  SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
                  DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
                  FormWhite to off-white solid
                  FormulationSupplied as an acetate salt.
                  CAS number117399-94-7
                  Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
                  Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
                  Purity≥96% by HPLC
                  Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
                  Storage -20°C
                  Protect from moisture
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
                  Toxicity Standard Handling
                  ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
                  Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
                  Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
                  Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
                  Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
                  Yanagisawa, M., et al. 1988. Nature 332, 411.