108975 Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

108975
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₃₈N₆O₄ . 1/2H₂SO₄103476-89-7

      Pricing & Availability

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      US1108975-100MG
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                      US1108975-5MG
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                          Description
                          OverviewA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
                          Catalogue Number108975
                          Brand Family Calbiochem®
                          SynonymsAc-LLR-CHO, ½H₂SO₄
                          References
                          ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                          Sarin, A., et al. 1994. J. Immunol. 153, 862.
                          Product Information
                          CAS number103476-89-7
                          ATP CompetitiveN
                          FormWhite lyophilized solid
                          Hill FormulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                          Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                          Hygroscopic Hygroscopic
                          ReversibleY
                          Structure formula ImageStructure formula Image
                          Applications
                          Biological Information
                          Primary Targettrypsin- and cysteine-like proteases
                          Purity≥90% by HPLC
                          Physicochemical Information
                          Cell permeableN
                          Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                          Dimensions
                          Materials Information
                          Toxicological Information
                          Safety Information according to GHS
                          Safety Information
                          Product Usage Statements
                          Storage and Shipping Information
                          Ship Code Ambient Temperature Only
                          Toxicity Standard Handling
                          Storage -20°C
                          Hygroscopic Hygroscopic
                          Do not freeze Ok to freeze
                          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                          Packaging Information
                          Transport Information
                          Supplemental Information
                          Specifications

                          Documentation

                          Certificates of Analysis

                          TitleLot Number
                          108975

                          References

                          Reference overview
                          Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                          Sarin, A., et al. 1994. J. Immunol. 153, 862.

                          Brochure

                          Title
                          Bulk Product Guide
                          Caspases and other Apoptosis Related Tools Brochure

                          Citations

                          Title
                        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                        • Data Sheet

                          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                          Revision29-March-2010 JSW
                          SynonymsAc-LLR-CHO, ½H₂SO₄
                          DescriptionA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
                          FormWhite lyophilized solid
                          CAS number103476-89-7
                          Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                          Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                          Structure formulaStructure formula
                          Purity≥90% by HPLC
                          SolubilityH₂O (50 mg/ml)
                          Storage -20°C
                          Hygroscopic
                          Do Not Freeze Ok to freeze
                          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                          Toxicity Standard Handling
                          Merck USA index14, 5456
                          ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                          Sarin, A., et al. 1994. J. Immunol. 153, 862.
                          Citation
                        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.