48-650MAG MILLIPLEX MAP 8-Plex Human Src Family Kinase Kit – Phosphoprotein - Cancer Multiplex Assay

48-650MAG
96-well plate  96-well plate
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      Blk (Tyr389), Fgr (Tyr412), Fyn (Tyr420), Hck (Tyr411), Lck (Tyr394), Lyn (Tyr397), Src (Tyr419), Yes (Tyr421)HMplexLuminex xMAP
      Description
      Catalogue Number48-650MAG
      Trade Name
      • MILLIPLEX
      DescriptionMILLIPLEX MAP 8-Plex Human Src Family Kinase Kit – Phosphoprotein - Cancer Multiplex Assay
      OverviewThe MILLIPLEX MAP 8-plex Human Src Family Kinase kit, phosphoprotein (pan Tyr), is used to detect tyrosine phosphorylation in Blk, Fgr, Fyn, Hck, Lck, Lyn, Src, and Yes in cell lysates using the Luminex® system. The detection assay is a rapid, convenient alternative to Western Blotting and immunoprecipitation procedures. Each kit has sufficient reagents for one 96 well plate assay.

      References:
      FASEB J. 2016 Sep 13. pii: fj.201500132. [Epub ahead of print]
      Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα.
      Karwad MA, Macpherson T, Wang B, Theophilidou E, Sarmad S, Barrett DA, Larvin M, Wright KL, Lund JN, O'Sullivan SE.
      References
      Product Information
      Detection methodLuminex xMAP
      ConfigurationPremixed
      Panel TypeCell Signaling
      Applications
      ApplicationIntracellular Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous relative quantitation of multiple phosphorylation and total pathway proteins in tissue and cell lysate samples. Compare Multiplexing results to those of Western blotting.
      Key Applications
      • Multiplexing
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • Blk (Tyr389)
      • Fgr (Tyr412)
      • Fyn (Tyr420)
      • Hck (Tyr411)
      • Lck (Tyr394)
      • Lyn (Tyr397)
      • Src (Tyr419)
      • Yes (Tyr421)
      Modifications
      • Phosphorylation
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size96-well plate
      Material Package96-well plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      8-Plex Src Family Kinase Magnetic Bead Kit -- 96-well Plate Assay

      MILLIPLEX MAP 8-Plex Human Src Family Kinase Kit – Phosphoprotein - Cancer Multiplex Assay SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion.
      Ariës, IM; Jerchel, IS; van den Dungen, RE; van den Berk, LC; Boer, JM; Horstmann, MA; Escherich, G; Pieters, R; den Boer, ML
      Leukemia  2014

      Show Abstract
      24625531 24625531
      Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.
      Sutton, P; Borgia, JA; Bonomi, P; Plate, JM
      Molecular cancer  12  76  2013

      Show Abstract
      23866081 23866081
      TNF-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
      Dhruv, Harshil D, et al.
      Carcinogenesis, (2013)  2013

      Show Abstract
      23975833 23975833
      LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
      Liu, Wenjin, et al.
      Cancer Cell, 21: 751-64 (2012)  2012

      Show Abstract
      22698401 22698401

      Brochure

      Title
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      Technical Info

      Title
      96 well Template 2 Up
      96 well Template Single

      Data Sheet

      Title
      Full Service Custom-built Assays

      Posters

      Title
      Cancer & Metastasis Signaling Pathways