Key Spec Table
|Key Applications||Format||Host||Detection Methods|
|Antibody Type||Monoclonal Antibody|
|Safety Information according to GHS|
|Product Usage Statements|
|Material Size||5 mL|
|Reference overview||Pub Med ID|
|Biological and ultrastructural properties of acelagraft, a freeze-dried γ-irradiated human amniotic membrane. |
Lim LS, Poh RW, Riau AK, Beuerman RW, Tan D, Mehta JS
Arch Ophthalmol 128 1303-10. 2010
OBJECTIVES: To compare the biological and ultrastructural properties of a commercially available decellularized and dehydrated human amniotic membrane (DDHAM) product with cryopreserved human amniotic membrane (CHAM) and to demonstrate the feasibility of DDHAM transplant in a case of chronic ocular surface disease.
|Evaluation of light diagnostics Simulfluor HSV/VZV immunofluorescence assay |
Scicchitano LM, et.al.
Diagn. Microbiol. Infect. Dis., 35:205-8 (1999) 1999
|Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. A cooperative regulation model for B cell clonal deletion. |
H Kamesaki, J A Zwiebel, J C Reed, J Cossman
Journal of immunology (Baltimore, Md. : 1950) 152 3294-305 1994
Recent studies of transgenic mice have confirmed that clonal deletion is involved in the development of B cells. However, little is known about intercellular and intracellular molecular events regulating B cell clonal deletion. We investigated the role of bcl-2 and cytokines in the regulation of B cell clonal deletion using anti-IgM-induced growth arrest and apoptosis in immature B cell lines as a model. We show here that overexpression of Bcl-2 protein in stably transfected immature B cells partially inhibits anti-Ig M-induced apoptosis but does not affect growth arrest. Similarly, IL-5 has a strong inhibitory effect on anti-IgM-mediated apoptosis but has a weak inhibitory effect on growth arrest. Finally, although both bcl-2 overexpression and exogenous IL-5 cooperate with bacterial LPS to block apoptosis, bcl-2 overexpression and exogenous IL-5 have no additive inhibitory effect on anti-Ig induced apoptosis. These findings indicate that anti-IgM-induced apoptosis is independently regulated from growth arrest and is controlled by at least two independent pathways: One is regulated by either Bcl-2 protein or IL-5 and the other is regulated by LPS. Activation of both the bcl-2/IL-5 and LPS pathways is necessary for complete inhibition of apoptosis, and presumably, clonal selection of the immature B cells.
|Light Diagnostics products for infectious disease|
|LIGHT DIAGNOSTICS KIT DFA SimulFluor HSV/VZV multi languages|
|LIGHT DIAGNOSTICS SimulFluor HSV/VZV DFA KIT|