676777 (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem

676777
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₇H₃₈N₂O₄ · HCl152-11-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      676777-100MG
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          Alu drum 100 mg
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          Description
          OverviewA papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
          Catalogue Number676777
          Brand Family Calbiochem®
          SynonymsL-Type Calcium Channel Blocker V
          References
          ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
          Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
          Product Information
          CAS number152-11-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₇H₃₈N₂O₄ · HCl
          Chemical formulaC₂₇H₃₈N₂O₄ · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channels
          Purity≥99% by titration (with perchloric acid)
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYV8320000
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          676777

          References

          Reference overview
          Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
          Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 309.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Title
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-May-2008 RFH
          SynonymsL-Type Calcium Channel Blocker V
          DescriptionA derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
          FormWhite solid
          CAS number152-11-4
          RTECSYV8320000
          Chemical formulaC₂₇H₃₈N₂O₄ · HCl
          Structure formulaStructure formula
          Purity≥99% by titration (with perchloric acid)
          SolubilityH₂O (70 mg/ml), Ethanol, or Methanol (50 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Toxic
          Merck USA index14, 9950
          ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
          Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
          Citation
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.