251010 | 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

251010
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₉H₁₃N₃O₅147-94-4

      Pricing & Availability

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      251010-1GM
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          1 gm
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          Description
          Overview Anticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
          Catalogue Number 251010
          Brand Family Calbiochem®
          Synonyms Ara-C, Cytarabine, Cytosine Arabinoside
          References
          References Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
          Product Information
          CAS number 147-94-4
          ATP Competitive N
          Form White solid
          Hill Formula C₉H₁₃N₃O₅
          Chemical formula C₉H₁₃N₃O₅
          Molar Mass 243.2
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Anticancer, antiviral agent that is especially effective against leukemias
          Physicochemical Information
          Cell permeable N
          Solubility H₂O
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS HA5425000
          Safety Information
          R Phrase R: 20/21/22-36/37/38-43-61

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          May cause harm to the unborn child.
          S Phrase S: 22-36-45

          Do not breathe dust.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          251010

          References

          Reference overview
          Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 30-April-2008 RFH
          Synonyms Ara-C, Cytarabine, Cytosine Arabinoside
          Description Cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3'-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons.
          Form White solid
          CAS number 147-94-4
          RTECS HA5425000
          Molar mass 243.2
          Chemical formula C₉H₁₃N₃O₅
          Structure formula
          Solubility H₂O (1 mM)
          Storage +2°C to +8°C
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index 14, 2784
          References Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.