658460 AG 879 - CAS 148741-30-4 - Calbiochem

658460
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₈H₂₄N₂OS148741-30-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      658460-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.
          Catalogue Number658460
          Brand Family Calbiochem®
          Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
          References
          ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
          Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
          Product Information
          CAS number148741-30-4
          ATP CompetitiveN
          FormOrange-yellow solid
          Hill FormulaC₁₈H₂₄N₂OS
          Chemical formulaC₁₈H₂₄N₂OS
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target(NGF)-dependent p140c-trk tyrosine phosphorylation
          Primary Target IC<sub>50</sub>EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



          From Catalog:
          Solubility- removed acetic acid, MeOH
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          658460

          References

          Reference overview
          Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
          Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-May-2011 RFH
          Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
          DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140c-trk tyrosine phosphorylation (EC50 = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC50 = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.
          FormOrange-yellow solid
          CAS number148741-30-4
          Chemical formulaC₁₈H₂₄N₂OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityAcetic acid, DMSO (100 mg/ml), or methanol
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



          From Catalog:
          Solubility- removed acetic acid, MeOH
          Toxicity Standard Handling
          ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
          Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
          Ohmichi, M., et al. 1993. Biochemistry 32, 4650.