505018 | ATPA - CAS 140158-50-5 - Calbiochem

505018
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₁₆N₂O₄140158-50-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.05018.0001
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          Glass bottle 1 mg
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          Description
          OverviewA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38 µM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and ∞ µM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22 µM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity.
          Catalogue Number505018
          Brand Family Calbiochem®
          Synonyms2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA
          Application Data
          References
          ReferencesLunn, ML., 2003. J. Med. Chem. 46, 872.
          Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
          Clarke, V., et al. 2002. Neuropharm. 42, 889.
          Kristensen, W., et al. 2001. Brain Res. 917, 21.
          Standley, S., et al. 1998. Exp. Neurol. 152, 208.
          Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
          Clarke, et al. 1997. Nature. 389, 599.
          Product Information
          CAS number140158-50-5
          FormWhite powder
          Hill FormulaC₁₀H₁₆N₂O₄
          Chemical formulaC₁₀H₁₆N₂O₄
          Applications
          Biological Information
          Primary TargetGluK1
          Purity≥97% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lunn, ML., 2003. J. Med. Chem. 46, 872.
          Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
          Clarke, V., et al. 2002. Neuropharm. 42, 889.
          Kristensen, W., et al. 2001. Brain Res. 917, 21.
          Standley, S., et al. 1998. Exp. Neurol. 152, 208.
          Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
          Clarke, et al. 1997. Nature. 389, 599.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2013 JSW
          Synonyms2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA
          Application Data
          DescriptionA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38 µM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and ∞ µM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22 µM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity.
          FormWhite powder
          CAS number140158-50-5
          Chemical formulaC₁₀H₁₆N₂O₄
          Purity≥97% by TLC
          SolubilityAqueous basic solutions
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLunn, ML., 2003. J. Med. Chem. 46, 872.
          Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
          Clarke, V., et al. 2002. Neuropharm. 42, 889.
          Kristensen, W., et al. 2001. Brain Res. 917, 21.
          Standley, S., et al. 1998. Exp. Neurol. 152, 208.
          Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
          Clarke, et al. 1997. Nature. 389, 599.