|Aerex 2 Hydrophobic Cartridge Filters -- High performance gas filters for use in industrial fermentation applications|
|The Effect of pH, Viscosity, and Additives on the Bacterial Retention of Membrane Filters Challenged with Pseudomonas Diminuta|
Levy, Richard,ASTM Special Publication 975 (1987).
ASTM Special Publication 975 (1987). 1987
|Sterile Filtration of Gases by Membrane Filters|
Leahy, Timothy J., and Raymond Gabler
Vol. XXVI: 836-843. 1984
|What is the difference between Aerex and Aervent?||Aervent cartridges have a 0.2µ PTFE membrane and are used in pharmaceutical applications where it is critical to use a phobic filter that has proven bacterial and viral retention capabilities. Common applications for Aervent are fermentation air applications, bioreactor inlet and outlet filtration and sterile process gases. Aervent filters have a liquid bacterial retention claim as well as a virus aerosol retention claim.
Aerex filters also have a 0.2µ PTFE membrane but they do not come with a liquid bacterial retention claim. Common applications for Aerex include bulk intermediate manufacturing and non-pharamaceutical applications such as industrial fermentation. Aerex filters do have a virus aerosol retention claim.
Aerex 2 hydrophobic cartridge filters provide high flow rates at low pressure differentials. Aerex 2 cartridge filters are manufactured using PTFE membrane and are 100 % integrity tested to assure optimal sterilizing performance. Each filter lot also must pass rigorous stress testing before release.
Designed to remove bacteria and viruses from moist gas streams, the filters are ideally suited for use in bulk pharmaceutical fermentation applications.
|Per 10-inch Cartridge|
|Materials of Construction|
|Cage and End Caps||Polypropylene|
|Filtration Area||0.66 m²|
|Maximum Differential Pressure, bar (psid)||Forward: 4.1 bar (60 psid) @ 25 °C; 0.35 bar (5 psid) @ 145 °C|
|Virus Aerosol Retention||Retention of a worst case challenge of the model bacteriophage Φ X-174 was complete at challenge levels up to 107 to 1010 virus particles at 1400 sL/min (50 scfm) after 200 steam sterilization cycles of 30 minutes at 145 °C|
|Bacterial Grow-Through||The membrane has been qualified to retain bacteria when challenged for 21 days with a minimum Brevundimonas diminuta aerosol concentration of 1 x 10⁷ CFU/cm².|
|Toxicity||Component materials meet the requirements of the USP Class VI Biological Test for Plastics. The cartridges also meet the requirements of the USP General (Mouse) Safety Test.|
|Sterilization||200 forward SIP cycles of 30 min @ 145 °C|
|Bubble Point||≥965 mbar (14 psig) nitrogen with 70/30 % IPA/water|
|Nitrogen Diffusion||≤60 mL/min @ 410 mbar (6.0 psig) in 70/30 % IPA/water|
|HydroCorr||≤0.40 mL/min per 10-inch cartridge with water @ 690 mbar (10 psig)|