171375 Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem

171375
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₄₇H₇₃NO₁₇1397-89-3

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      171375-100MG
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          Glass bottle 100 mg
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          Description
          OverviewA polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.
          Catalogue Number171375
          Brand Family Calbiochem®
          SynonymsFungizone
          References
          ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
          Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
          Barth, C., et al. 1993. J. Biophys. 64, 92.
          Product Information
          CAS number1397-89-3
          FormYellow solid
          Hill FormulaC₄₇H₇₃NO₁₇
          Chemical formulaC₄₇H₇₃NO₁₇
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity>86% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSBU2625000
          Safety Information
          R PhraseR: 20/21-36/37/38

          Harmful by inhalation and in contact with skin.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          171375

          References

          Reference overview
          Tollemar, J., et al. 1995. Transplantation 59, 45.
          Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
          Barth, C., et al. 1993. J. Biophys. 64, 92.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-July-2007 RFH
          SynonymsFungizone
          DescriptionAn antifungal agent. A polyene antibiotic that nonspecifically induces the loss of low molecular weight substances from cells. Causes suppression of bone marrow progenitor cells. Probably forms channels by complexing with membrane cholesterol. Effective against fungi and yeast at concentrations of 1-10 µg/ml.
          FormYellow solid
          CAS number1397-89-3
          RTECSBU2625000
          Chemical formulaC₄₇H₇₃NO₁₇
          Structure formulaStructure formula
          Purity>86% by HPLC
          SolubilityDMF or DMSO (30-40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
          Toxicity Harmful
          Merck USA index14, 585
          ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
          Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
          Barth, C., et al. 1993. J. Biophys. 64, 92.