05-632 | Anti-14-3-3σ Antibody, clone CS112-2A8

05-632
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-632
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-14-3-3σ Antibody, clone CS112-2A8
      Alternate Names
      • Stratifin
      References
      Product Information
      FormatPurified
      Control
      • Positive Control Included: EGF stim A431 Cell Lysate (12-302). Other controls: Lung tissue
      PresentationProtein G Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      Applications
      ApplicationDetect 14-3-3σ using this Anti-14-3-3σ Antibody, clone CS112-2A8 validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to full-length human 14-3-3 sigma
      CloneCS112-2A8
      HostMouse
      SpecificityRecognizes 14-3-3σ, does not cross-react with other 14-3-3 isoforms.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SFN
      • YWHAS
      • HME1
      • stratifin
      • Stratifin
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.
      SIZE: 248 amino acids; 27774 Da
      SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
      TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
      SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family.
      Molecular Weight30 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates of EGF-stimulated A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-14-3-3s, clone CS112-2A8 (mouse monoclonal IgG1k) - 2297221 2297221
      Anti-14-3-3sigma;, clone CS112-2A8 - 22077 22077
      Anti-14-3-3sigma;, clone CS112-2A8 - 29506 29506
      Anti-14-3-3sigma;, clone CS112-2A8 - 33344 33344
      Anti-14-3-3sigma;, clone CS112-2A8 - JBC1361702 JBC1361702
      Anti-14-3-3σ, clone CS112-2A8 -2557636 2557636
      Anti-14-3-3σ, clone CS112-2A8 -2774111 2774111

      References

      Reference overviewApplicationPub Med ID
      Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells.
      Matthew C Catley, Joanna E Chivers, Neil S Holden, Peter J Barnes, Robert Newton
      British journal of pharmacology  145  114-22  2005

      Show Abstract Full Text Article
      15723090 15723090
      BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity
      Zha, J., et al
      J Biol Chem, 272:24101-4 (1997)  1997

      Immunoblotting (Western), Immunoprecipitation9305851 9305851

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      Included Positive Control

      Catalogue Number Description  
      12-302 EGF-Stimulated A431 Cell Lysate Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies