09-281 | Anti-19S regulator non-ATPase subunit S9/Rpn6 Antibody | 09-281

09-281
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIF, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number09-281
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-19S regulator non-ATPase subunit S9/Rpn6 Antibody | 09-281
      Alternate Names
      • 26S proteasome non-ATPase subunit 11
      • S9
      References
      Product Information
      FormatPurified
      Presentation100 µL of purified immunoglobulin in 50% glycerol, 50% PBS containing 0.01 M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
      Applications
      Key Applications
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to the C-terminal region of the Arabidopsis thaliana Rpn6 protein.
      HostRabbit
      SpecificityRecognizes 19S regulator non-ATPase subunit S9/Rpn6.
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NoteArabisopsis and cauliflower. Reactivity with other species has not been confirmed.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.
      Gene Symbol
      • PSMD11
      • S9
      • p44.5
      • MGC3844
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00231 # Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
      SIZE: 422 amino acids; 47464 Da
      SUBUNIT: Component of the PA700 complex.
      SIMILARITY: SwissProt: O00231 ## Contains 1 PCI domain.
      Molecular Weight47 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overviewPub Med ID
      Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex
      Kwok, S F, et al
      J Mol Biol, 285:85-95 (1999)  1999

      9878390 9878390
      The 26S proteasome: subunits and functions
      Tanaka, K and Tsurumi, C
      Mol Biol Rep, 24:3-11 (1997)  1997

      9228274 9228274
      Subunits of the regulatory complex of the 26S protease.
      Dubiel, W, et al.
      Mol. Biol. Rep., 21: 27-34 (1995)  1995

      7565660 7565660