05-1149 | Anti-ADP-Ribosylation Factor 6 Antibody, clone 6ARF01

05-1149
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1149
      ReplacesMAB1131
      DescriptionAnti-ADP-Ribosylation Factor 6 Antibody, clone 6ARF01
      Alternate Names
      • ADP-ribosylation factor 6
      Background InformationADP-Ribosylation Factor 6 (ARF6) is a GTP-binding protein that functions as a regulator of cytoskeleton remodeling and endocytic recycling. ARF6 is an allosteric activator of cholera toxin catalytic subunit, an ADP-ribosyltransferase. It may also be involved in the modulation of vesicle budding and uncoating with the Golgi apparatus.
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 Cell Lysate
      PresentationPurified monoclonal IgG ascites in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
      Applications
      ApplicationAnti-ADP-Ribosylation Factor 6 Antibody, clone 6ARF01 is a Mouse Monoclonal Antibody for detection of ADP-Ribosylation Factor 6 also known as ADP-ribosylation factor 6 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant human ARF6 protein.
      Clone6ARF01
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes ADP-ribosylation factor (ARF) 6.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DKFZp564M0264
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62330 # GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
      SIZE: 175 amino acids; 20082 Da
      SUBUNIT: Interacts with ARHGAP21, DDEF2, PIP5K1C and UACA.
      SIMILARITY: SwissProt: P62330 ## Belongs to the small GTPase superfamily. Arf family.
      Molecular WeightApprox. 19-20 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated in Western Blot on NIH/3T3 cell lysates.
      Western Blot Analysis: 1:500 dilution of this antibody detected ARF6 in 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8ºC in undiluted aliquots for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2146007 2146007
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2385967 2385967
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2407517 2407517
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2433384 2433384
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 1941613 1941613
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 1995598 1995598
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2012967 2012967
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2022064 2022064
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2063209 2063209
      Anti-ADP-Ribosylation Factor 6, clone 6ARF01 - 2110546 2110546

      References

      Reference overviewPub Med ID
      ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock.
      Davis, CT; Zhu, W; Gibson, CC; Bowman-Kirigin, JA; Sorensen, L; Ling, J; Sun, H; Navankasattusas, S; Li, DY
      Journal of immunology (Baltimore, Md. : 1950)  192  6045-52  2014

      Show Abstract
      24835390 24835390

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies