09-069 | Anti-ATF6 Antibody

09-069
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-069
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-ATF6 Antibody
      Background InformationATF6 (Activating Transcription Factor 6, Cyclic AMP-dependent transcription factor ATF6) is a stress activated leucine zipper transcription factor involved in activating transcription of endoplasmic reticulum (ER) molecules in response to accumulation of unfolded proteins in the ER. ATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. Unfolded protein accumulation in the ER results in the cleavage of ATF6 to release its cytoplasmic domain that then enters the nucleus. ATF6 binds to an element designated ER Stress Response Element (ERSA) that appears in the promoter of glucose-regulated proteins (GRPs) such as GRP78, GPR94, and calreticulin.
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationDetect ATF6 using this Anti-ATF6 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-tagged synthestic peptide synthesized to the N-terminal region of human ATF6 designated as the Cytoplasmic Domain.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ATF6
      • activating transcription factor 6
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight90 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on HeLa lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications