05-771 | Anti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal

05-771
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-771
      Replaces04-406
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Akt2/PKBβ Antibody, clone AW114, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
      Applications
      ApplicationDetect Akt2/PKBβ using this Anti-Akt2/PKBβ Antibody, clone AW114 validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPeptide (C-RYDSLGSLELDQRTH) corresponding to amino acids 455-469 of human Akt2/PKBb
      Cloneclone AW114
      HostRabbit
      SpecificityAkt2/PKBβ
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NotePredicted to cross-react with mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
      Gene Symbol
      • AKT2
      • RAC-BETA
      • PRKBB
      • PKBBETA
      • RAC-PK-beta
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31751 # General protein kinase capable of phosphorylating several known proteins.
      SIZE: 481 amino acids; 55769 Da
      TISSUE SPECIFICITY: In all human cell types so far analyzed.
      DISEASE:SwissProt: P31751 # Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.
      SIMILARITY: SwissProt: P31751 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
      Molecular Weight~60kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from rat L6 skeletal muscle cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Akt2/PKB#946;, clone AW114 - DAM1785847 DAM1785847
      Anti-Akt2/PKBb, clone AW114 (rabbit monoclonal IgG) - 2199736 2199736
      Anti-Akt2/PKBb, clone AW114 (rabbit monoclonal IgG) - 2281647 2281647
      Anti-Akt2/PKBb, clone AW114 - 1991314 1991314
      Anti-Akt2/PKBb, clone AW114 - 2073107 2073107
      Anti-Akt2/PKBbeta;, clone AW114 - 26808 26808

      References

      Reference overviewPub Med ID
      Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
      James, SR; Downes, CP; Gigg, R; Grove, SJ; Holmes, AB; Alessi, DR
      The Biochemical journal  315 ( Pt 3)  709-13  1996

      Show Abstract
      8645147 8645147
      Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
      Cross, D A, et al.
      Nature, 378: 785-9 (1995)  1995

      Show Abstract
      8524413 8524413

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies