05-930 | Anti-Alpha4 Antibody, clone 5F6

05-930
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number05-930
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Alpha4 Antibody, clone 5F6
      References
      Product Information
      FormatCulture Supernatant
      Applications
      ApplicationThis Anti-Alpha4 Antibody, clone 5F6 is validated for use in WB for the detection of Alpha4.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenN-terminal 6His-tagged fusion protein corresponding to full length mouse Alpha4
      Clone5F6
      HostMouse
      SpecificityAlpha4
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodMouse culture supernatant
      UniProt Number
      Molecular Weight40kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on RIPA lysates from HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Alpha4, clone 5F6 - 30472 30472
      Anti-Alpha4, clone 5F6 -2607877 2607877
      Anti-Alpha4, clone 5F6 -2767032 2767032
      Anti-Alpha4, clone 5F6 -2796824 2796824

      References

      Reference overviewPub Med ID
      Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
      Wengrod, J; Wang, D; Weiss, S; Zhong, H; Osman, I; Gardner, LB
      Science signaling  8  ra27  2015

      Show Abstract
      25759478 25759478
      Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.
      Wong, PM; Feng, Y; Wang, J; Shi, R; Jiang, X
      Nature communications  6  8048  2015

      Show Abstract
      26310906 26310906
      Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules.
      Berti, Caterina, et al.
      BMC Cell Biol., 5: 9 (2004)  2004

      15070402 15070402
      The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.
      Kong, Mei, et al.
      Science, 306: 695-8 (2004)  2004

      Show Abstract
      15499020 15499020
      Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.
      Kloeker, Susanne, et al.
      Protein Expr. Purif., 31: 19-33 (2003)  2003

      Show Abstract
      12963337 12963337
      Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome.
      Everett, Allen D and Brautigan, David L
      Dev. Dyn., 224: 461-4 (2002)  2002

      Show Abstract
      12203739 12203739
      Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.
      Liu, J, et al.
      Proc. Natl. Acad. Sci. U.S.A., 98: 6650-5 (2001)  2001

      Show Abstract
      11371618 11371618
      B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A.
      Murata, K, et al.
      Proc. Natl. Acad. Sci. U.S.A., 94: 10624-9 (1997)  1997

      Show Abstract
      9380685 9380685