06-680-AF488 | Anti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate

06-680-AF488
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Uni Prot Number
      P15207
      Description
      Catalogue Number06-680-AF488
      DescriptionAnti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Androgen receptor
      • Dihydrotestosterone receptor
      • Nuclear receptor subfamily 3 group C member 4
      Background InformationAndrogen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Applications
      ApplicationDetect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor® 488 Conjugate validated for use in Immunocytochemistry.
      Key Applications
      • Immunocytochemistry
      Application NotesThe unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.
      EpitopeThis antibody recognizes the Modulating Region within the N-terminal of androgen receptor.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Mouse, Bovine, Horse, Canine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ar
      • Andr, Nr3c4
      • Tfm
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~110 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in MCF-7 cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest