06-1050 | Anti-Axin-2 Antibody

06-1050
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1050
      DescriptionAnti-Axin-2 Antibody
      Alternate Names
      • Axin-2
      • Axin-like protein
      • Axil
      • Axis inhibition protein 2
      • Conductin
      Background InformationAxis inhibition protein 2 (Axin-2) has been linked to selective tooth angenesis. It has been found in human thymus, prostate, testis, small intestine, ovarian tissue and in the colon, at a lower expression rate. Axin-2 is involved during skull morphogenesis and missing Axin-2 can cause abnormal skull morphology. Variation in Axin-2 has been associated with accelerated chondrocyte proliferation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • SW620 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Axin-2 Antibody detects level of Axin-2 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: 1:500 dilution from a representative lot detected Axin-2 in colorectal cancer and multiform glioblastoma tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Axin-2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq].
      Gene Symbol
      • AXIN2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

      SUBUNIT STRUCTURE: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICITY: Expressed in brain and lymphoblast.

      PTM: Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).

      INVOLVEMENT IN DISEASE: Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.

      Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

      SEQUENCE SIMILARITIES: Contains 1 DIX domain.

      Contains 1 RGS domain.
      Molecular Weight~85 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in SW620 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Axin-2 on 10 µg of SW620 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies