04-082 | Anti-BAF155/170 Antibody, clone DXD12

04-082
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-082
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-BAF155/170 Antibody, clone DXD12
      References
      Product Information
      FormatPurified
      Presentation100 μg of Protein A purified mouse monoclonal IgG in 100μl of 1X PBS, pH 7.0, 0.1% Azide.
      Applications
      ApplicationThis Anti-BAF155/170 Antibody, clone DXD12 is validated for use in WB for the detection of BAF155/170.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to residues 591-608 of human BAF155.
      Cloneclone DXD12
      HostMouse
      SpecificityBAF155/170
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.
      Gene Symbol
      • SMARCC1
      • CRACC1
      • SRG3
      • BAF155
      • SWI3
      • Rsc8
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92922 # Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex.
      SIZE: 1105 amino acids; 122753 Da
      SUBUNIT: Component of five multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Interacts with NR3C1 and SMARD1.
      SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
      PTM: Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.
      SIMILARITY: SwissProt: Q92922 ## Belongs to the SMARCC family. & Contains 1 SANT domain. & Contains 1 SWIRM domain.
      Molecular Weight155/170 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunoblot Analysis: A 1:1000 dilution of this antibody detected BAF155/170 in HeLa nuclear extracts.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-BAF155/170, clone DXD12 -2632462 2632462

      References

      Reference overviewPub Med ID
      Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57
      Chen, Jianguang and Archer, Trevor K
      Mol Cell Biol, 25:9016-27 (2005)  2005

      16199878 16199878

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies