04-433 | Anti-Bak Antibody, rabbit monoclonal

04-433
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Human OnlyFC, IF, WB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-433
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Bak Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Bak Antibody, Rabbit detects level of Bak & has been published & validated for use in FC, IF, WB, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bak.
      HostRabbit
      SpecificityRecognizes a region near the N-terminus domain of human Bak.
      IsotypeIgG
      Species Reactivity
      • Human Only
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
      Gene Symbol
      • BAK1
      • CDN1
      • BAK
      • BAK-LIKE
      • MGC3887
      • BCL2L7
      • OTTHUMP00000039620
      • MGC117255
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16611 # In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.
      SIZE: 211 amino acids; 23409 Da
      SUBUNIT: Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl- X(L).
      SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
      TISSUE SPECIFICITY: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
      DOMAIN:SwissProt: Q16611 Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
      SIMILARITY: Belongs to the Bcl-2 family.
      Molecular Weight~23 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Bak (Rabbit monoclonal IgG) - 2397051 2397051
      Anti-Bak (Rabbit monoclonal IgG) - 2211912 2211912
      Anti-Bak (Rabbit monoclonal IgG) - 2275535 2275535
      Anti-Bak - DAM1475057 DAM1475057
      Anti-Bak - DAM1519001 DAM1519001
      Anti-Bak - DAM1655286 DAM1655286
      Anti-Bak - DAM1772444 DAM1772444
      Anti-Bak - DAM1785874 DAM1785874
      Anti-Bak - NG1805273 NG1805273
      Anti-Bak - NG1849474 NG1849474

      References

      Reference overviewPub Med ID
      Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent.
      Wang, Y; Lv, J; Cheng, Y; Du, J; Chen, D; Li, C; Zhang, J
      PloS one  10  e0124812  2015

      Show Abstract
      25860257 25860257
      Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.
      Guglielmotto, M; Monteleone, D; Piras, A; Valsecchi, V; Tropiano, M; Ariano, S; Fornaro, M; Vercelli, A; Puyal, J; Arancio, O; Tabaton, M; Tamagno, E
      Autophagy  10  1827-43  2014

      Show Abstract
      25136804 25136804
      Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
      Zhang, L; Lopez, H; George, NM; Liu, X; Pang, X; Luo, X
      Cell death and differentiation  18  864-73  2011

      Show Abstract Full Text Article
      21113147 21113147
      Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage.
      Lopez, H; Zhang, L; George, NM; Liu, X; Pang, X; Evans, JJ; Targy, NM; Luo, X
      The Journal of biological chemistry  285  15016-26  2010

      Show Abstract Full Text Article
      20223826 20223826
      The RNA component of human telomerase
      Feng, J, et al
      Science, 269:1236-41 (1995)  1995

      7544491 7544491
      Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
      Greider, C W and Blackburn, E H
      Cell, 43:405-13 (1985)  1985

      3907856 3907856

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies