Key Spec Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|H||IF, IP, WB, IH(P)||Rb||Purified||Monoclonal Antibody|
|Description||Anti-Bcl-6 (CT) Antibody, rabbit monoclonal|
|Presentation||In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.|
|Application||Detect Bcl-6 (C-term) using this Anti-Bcl-6 (C-term) Antibody, Rabbit validated for use in IF, IP, WB, IH(P).|
|Safety Information according to GHS|
|Material Size||100 µL|
|Reference overview||Pub Med ID|
|BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control|
Shaffer, A L, et al
Immunity, 13:199-212 (2000) 2000
|LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.|
Kerckaert, J P, et al.
Nat. Genet., 5: 66-70 (1993) 1993
We have shown previously that chromosomal translocations involving chromosome 3q27 and immunoglobulin gene regions are the third most common specific translocations in non-Hodgkin's lymphoma (NHL). We now report the isolation of a gene that is disrupted in two cases by t(3;14) and t(3;4) translocations. The gene (LAZ3) encodes a 79 kDa protein containing six zinc-finger motifs and sharing amino-terminal homology with several transcription factors including the Drosophila tramtrack and Broad-complex genes, both of which are developmental transcription regulators. LAZ3 is transcribed as a 3.8 kb message predominantly in normal adult skeletal muscle and in several NHL carrying 3q27 chromosomal defects. We suggest that it may act as a transcription regulator and play an important role in lymphomagenesis.