04-437 | Anti-Bcl-6 (CT) Antibody, rabbit monoclonal

04-437
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIF, IP, WB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-437
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Bcl-6 (CT) Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationDetect Bcl-6 (C-term) using this Anti-Bcl-6 (C-term) Antibody, Rabbit validated for use in IF, IP, WB, IH(P).
      Key Applications
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide near the C-terminus of human Bcl-6.
      HostRabbit
      SpecificityRecognizes a region near the C-terminus of human Bcl-6.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL.
      Gene Symbol
      • BCL6
      • ZBTB27
      • BCL-5
      • ZNF51
      • BCL-6
      • LAZ3
      • BCL6A
      • BCL5
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41182 # Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
      SIZE: 706 amino acids; 78846 Da
      SUBUNIT: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.
      SUBCELLULAR LOCATION: Nucleus (By similarity).
      TISSUE SPECIFICITY: Expressed in germinal center T and B cells and in primary immature dendritic cells.
      PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
      DISEASE: SwissProt: P41182 # Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. & A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. & A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
      SIMILARITY: SwissProt: P41182 ## Contains 1 BTB (POZ) domain. & Contains 6 C2H2-type zinc fingers.
      Molecular Weight87-98 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 2121719 2121719
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 2349463 2349463
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 2434068 2434068
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 1999440 1999440
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 2195974 2195974
      Anti-Bcl-6 (C-term) (Rabbit monoclonal IgG) - 2317757 2317757
      Anti-Bcl-6 (C-term) - 2028224 2028224
      Anti-Bcl-6 (C-term) - DAM1731533 DAM1731533
      Anti-Bcl-6 (C-term), Rabbit Monoclonal - 0611046378 0611046378

      References

      Reference overviewPub Med ID
      BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
      Shaffer, A L, et al
      Immunity, 13:199-212 (2000)  2000

      10981963 10981963
      LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.
      Kerckaert, J P, et al.
      Nat. Genet., 5: 66-70 (1993)  1993

      Show Abstract
      8220427 8220427

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies