09-031 | Anti-CBX8 Antibody

09-031
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number09-031
      DescriptionAnti-CBX8 Antibody
      Alternate Names
      • Polycomb 3 homolog
      • Rectachrome 1
      • chromobox homolog 8
      • chromobox homolog 8 (Drosophila Pc class)
      • chromobox homolog 8 (Pc class homolog, Drosophila), polycomb 3
      Background InformationThe family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin.
      References
      Product Information
      FormatPurified
      Control
      • NIH/3T3 nuclear extract, HeLa cell nuclear extract
      PresentationPurified rabbit polyclonal in buffer containing PBS and 0.05% sodium azide.
      Applications
      ApplicationUse Anti-CBX8 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect CBX8 also known as Rectachrome 1, chromobox homolog 8.
      Key Applications
      • Western Blotting
      Application NotesSNAP I.D. (western blotting technique): A previous lot of this antibody worked successfully using the SNAP I.D. western blotting device and technique.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the postchromo domain of CBX8.
      EpitopePostchromo Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody detects the postchromo domain of CBX8.
      Species Reactivity
      • Mouse
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HPC3
      • PC3
      • Pc3
      • RC1
      • hPc3
      Purification MethodProtein A purifed with GST depletion
      UniProt Number
      UniProt SummaryFUNCTION: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

      SUBUNIT STRUCTURE: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with MLLT3.

      SUBCELLULAR LOCATION: Nucleus.

      SEQUENCE SIMILARITIES: Contains 1 chromo domain.

      Molecular Weight~42 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on HeLa nuclear extract.

      Western Blot Analysis: 1-2 µg/mL of this antibody detected CBX8 in HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-CBX8 - 2033658 2033658
      Anti-CBX8 - NG1618261 NG1618261
      Anti-CBX8 -2515717 2515717
      Anti-CBX8 -2544312 2544312
      Anti-CBX8 -2582831 2582831
      Anti-CBX8 -2606264 2606264

      References

      Reference overviewPub Med ID
      Altered expression of polycomb group genes in glioblastoma multiforme.
      Li, G; Warden, C; Zou, Z; Neman, J; Krueger, JS; Jain, A; Jandial, R; Chen, M
      PloS one  8  e80970  2013

      Show Abstract
      24260522 24260522

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies