04-158 | Anti-CD137L/4-1BBL Antibody, clone TKS-1

04-158
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-158
      DescriptionAnti-CD137L/4-1BBL Antibody, clone TKS-1
      Alternate Names
      • 4-1BB ligand
      • homolog of mouse 4-1BB-L
      • receptor 4-1BB ligand
      • tumor necrosis factor (ligand) superfamily, member 9
      Background InformationTumor necrosis factor receptor ligand superfamily member 9 (also known as CD137L, 4-1BBL or 4-1BB ligand) is a ligand for CD137, a member of the tumor necrosis factor (TNF) receptor family and is induced by lymphocyte activation (ILA). CD137 can be expressed by activated T cells, but more so on CD8 rather than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 interacts with TRAF1, TRAF2 and TRAF3, as well as LRR-repeat protein 1/LRR-1. CD137 exhibits costimulatory activity for activated T cells, where the crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 may also enhance immune activity towards tumor suppression.
      References
      Product Information
      FormatPurified
      Control
      • RAW264.7 cells
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-CD137L/4-1BBL Antibody, clone TKS-1 detects level of CD137L/4-1BBL & has been published & validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMouse 4-1BBL cDNA-transfected NRK cells.
      EpitopeUnknown
      CloneTKS-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThis antibody recognizes CD137L/4-1BBL.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TNFS9
      • 4-1BB-L
      • 4-1BBL
      • CD137L
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

      SUBUNIT STRUCTURE: Homotrimer Potential.

      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.
      Molecular Weight~ 34 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in RAW264.7 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected CD137L/4-1BBL in RAW264.7 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications