CBL1366 | Anti-CD140a Antibody, clone APA5

CBL1366
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISA, FC, WB, IHC, FUNCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL1366
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD140a Antibody, clone APA5
      Alternate Names
      • PDGF Receptor alpha
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin in PBS, 150 mM NaCl, pH 7.2, containing 0.09% sodium azide.
      Applications
      ApplicationDetect CD140a using this Anti-CD140a Antibody, clone APA5 validated for use in ELISA, FC, WB, IH.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry
      • Affects Function
      Application NotesFlow Cytometry: <= 1 μg per 10E6 cells

      ELISA

      Immunohistochemistry: 10μg/mL

      Blocking of Ligand Binding

      Western Blotting

      Optimal working dilutions must be determined by the end user.
      Biological Information
      CloneAPA5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificitySpecifically recognizes mouse CD140a, the alpha chain of PDGF receptor. A receptor tyrosine kinase, PDGFRa forms dimers on the surface upon ligand binding and phosphorylates substrates. CD140a is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
      Gene Symbol
      • PDGFRA
      • CD140a
      • PDGFR2
      • Rhe-PDGFRA
      • PDGF-R-alpha
      • CD140A
      • MGC74795
      • EC 2.7.10.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
      SIZE: 1089 amino acids; 122670 Da
      SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
      SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      RAT ANTI-MOUSE CD140a -2618505 2618505
      RAT ANTI-MOUSE CD140a -2654652 2654652
      RAT ANTI-MOUSE CD140a -2718340 2718340
      RAT ANTI-MOUSE CD140a -2757187 2757187
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY 2909651
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY - 2025956 2025956
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY - 2070394 2070394
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY - 2219294 2219294
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY - 2322550 2322550
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY - 2552328 2552328

      References

      Reference overviewApplicationPub Med ID
      Ciliary neurotrophic factor controls progenitor migration during remyelination in the adult rodent brain.
      Vernerey, J; Macchi, M; Magalon, K; Cayre, M; Durbec, P
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  3240-50  2013

      Show Abstract
      Western Blotting23407977 23407977

      Data Sheet

      Title
      RAT ANTI-MOUSE CD140a MONOCLONAL ANTIBODY

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies