CBL475 | Anti-CD1b Antibody, clone WM25

CBL475
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL475
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD1b Antibody, clone WM25
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-CD1b Antibody, clone WM25 is an antibody against CD1b for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesAnalysis of early stages of T cell differentiation

      Immunodiagnosis of certain acute lymphoblastic leukaemias and high grade T cell non-Hodgkins lymphomas

      Immunoprecipitation studies of the CD1b antigen

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman thymocytes and splenic lymphocytes
      CloneWM25
      HostMouse
      SpecificityThis antibody reacts with an epitope distinct from human thymocyte antigen - 1 (43 kDa) that is expressed on the majority of thymocytes and approximately 50% of cases of T ALL. This antibody does not stain Langerhans cells.

      Antigen distribution:

      Thymocytes 80 ± 10%

      Granulocytes < 1%

      Monocytes < 1%

      B cells (E+) < 1%

      T cells (E-) < 1%

      Peripheral blood lymphocytes < 1%

      FUSION PARTNER: NS1 myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
      Gene Symbol
      • CD1B
      • R1
      • CD1
      • MGC125991
      • MGC125990
      • CD1A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29016 # Not known.
      SIZE: 333 amino acids; 36939 Da
      SUBUNIT: Associates non-covalently with beta-2-microglobulin.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
      SIMILARITY: SwissProt: P29016 ## Contains 1 Ig-like (immunoglobulin-like) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications