04-455 | Anti-CD20 (CT) Antibody, rabbit monoclonal

04-455
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-455
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-CD20 (CT) Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-CD20 (C-term) Antibody, Rabbit detects level of CD20 (C-term) & has been published & validated for use in IP, WB, IH(P).
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide composed of residues at the C-terminus of human CD20.
      HostRabbit
      SpecificityRecognizes a region composed of residues at the C-terminus of human CD20.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
      Gene Symbol
      • MS4A1
      • LEU-16
      • B1
      • MS4A2
      • Leu-16
      • CD20
      • Bp35
      • S7
      • MGC3969
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P11836 # This protein may be involved in the regulation of B-cell activation and proliferation.
      SIZE: 297 amino acids; 33077 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed on B-cells.
      PTM: Phosphorylated. Might be functionally regulated by protein kinase(s).
      SIMILARITY: SwissProt: P11836 ## Belongs to the MS4A family.
      Molecular Weight35kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-CD20 (C-term) 2436303
      Anti-CD20 (C-term) (Rabbit monoclonal IgG) - 2390342 2390342
      Anti-CD20 (C-term) (Rabbit monoclonal IgG) - DAM1421470 DAM1421470
      Anti-CD20 (C-term) - 2428510 2428510
      Anti-CD20 (C-term) - 2502866 2502866
      Anti-CD20 (C-term) - DAM1597406 DAM1597406
      Anti-CD20 (C-term) - NG1643004 NG1643004
      Anti-CD20 (C-term) - NG1660757 NG1660757
      Anti-CD20 (C-term) - NG1722239 NG1722239
      Anti-CD20 (C-term) - NG1743538 NG1743538

      References

      Reference overviewPub Med ID
      [Guideline for radioimmunotherapy of rituximab relapsed or refractory CD20(+) follicular B-cell non-Hodgkin's lymphoma]
      Fischer, M, et al.
      Nuklearmedizin. Nuclear medicine, 43: 171-6 (2004)  2004

      Show Abstract
      15480506 15480506
      Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)
      Tedder, T F, et al
      J Immunol, 142:2560-8 (1989)  1989

      2466899 2466899

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies