04-460 | Anti-CD3 ε Antibody, rabbit monoclonal

04-460
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIF, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-460
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-CD3 ε Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect CD3 ε using this Anti-CD3 ε Antibody, Rabbit validated for use in IF & WB.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide composed of residues encompassing the cytoplasmic domain of human CD3.
      HostRabbit
      SpecificityRecognizes a region composed of residues encompassing the cytoplasmic domain of human CD3. This antibody does not recognize the other subunits of CD3.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
      Gene Symbol
      • CD3E
      • T3E
      • TCRE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07766 # The CD3 complex mediates signal transduction.
      SIZE: 207 amino acids; 23147 Da
      SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P07766 ## Contains 1 Ig-like (immunoglobulin-like) domain. & Contains 1 ITAM domain.
      Molecular Weight23kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-CD3 epsilon - 1974459 1974459
      Anti-CD3 epsilon - DAM1546237 DAM1546237
      Anti-CD3 epsilon - DAM1644594 DAM1644594
      Anti-CD3 epsilon - NG1853184 NG1853184
      Anti-CD3 epsilon, Rabbit Monoclonal - 0611046365 0611046365

      References

      Reference overviewPub Med ID
      Multiple signal transduction pathways activated through the T cell receptor for antigen
      Siegel, J N, et al
      Semin Immunol, 3:325-34 (1991)  1991

      1724737 1724737
      Signal transduction by the T cell antigen receptor.
      Weiss, A, et al.
      Semin. Immunol., 3: 313-24 (1991)  1991

      Show Abstract
      1839225 1839225

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies