05-756 | Anti-Calsenilin/DREAM Antibody, clone 40A5

05-756
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-756
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Calsenilin/DREAM Antibody, clone 40A5
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationDetect Calsenilin/DREAM using this Anti-Calsenilin/DREAM Antibody, clone 40A5 validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenFull length GST fusion protein of human Calsenilin/DREAM
      Cloneclone 40A5
      HostMouse
      SpecificityCalsenilin/DREAM
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
      Gene Symbol
      • KCNIP3
      • MGC18289
      • KChIP3
      • DREAM
      • CSEN
      • calsenilin
      • Calsenilin
      • KCHIP3
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y2W7 # May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
      SIZE: 256 amino acids; 29231 Da
      SUBUNIT: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3 (By similarity). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1.
      SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.
      TISSUE SPECIFICITY: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
      PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). & Proteolytically cleaved by caspase-3.
      SIMILARITY: SwissProt: Q9Y2W7 ## Belongs to the recoverin family. & Contains 4 EF-hand domains.
      Molecular Weight~30kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA homogenate from human Alzheimers diseased brain
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Calsenilin/DREAM, clone 40A5 2476953
      Anti-Calsenilin/DREAM, clone 40A5 - 26762 26762
      Anti-Calsenilin/DREAM, clone 40A5 -2844282 2844282
      Anti-Calsenilin/DREAM, clone 40A5, (mouse ascites) 2839444

      References

      Reference overviewPub Med ID
      Independent genomic control of neuronal number across retinal cell types.
      Keeley, PW; Whitney, IE; Madsen, NR; St John, AJ; Borhanian, S; Leong, SA; Williams, RW; Reese, BE
      Developmental cell  30  103-9  2014

      Show Abstract
      24954025 24954025
      Modulation of A-type potassium channels by a family of calcium sensors.
      An, W F, et al.
      Nature, 403: 553-6 (2000)  2000

      10676964 10676964
      DREAM is a Ca2+-regulated transcriptional repressor.
      Carrión, A M, et al.
      Nature, 398: 80-4 (1999)  1999

      Show Abstract
      10078534 10078534
      Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
      Buxbaum, J D, et al.
      J. Biol. Chem., 273: 27765-7 (1998)  1998

      Show Abstract
      9774383 9774383